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- 학과정보 : 의학과 내과학 전공 (검색결과 4,081 건)
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Association of Blood Eosinophilia with Disease Severity and Clinical Outcomes in Bronchiectasis
강유리 순천향대학교 일반대학원 2026 국내석사
Bronchiectasis is a heterogeneous chronic airway disease with variable inflammatory profiles and clinical outcomes. Although neutrophilic inflammation predominates, eosinophilic inflammation has been identified in a subset of patients. However, the clinical significance of blood eosinophilia in bronchiectasis remains unclear, particularly regarding disease severity, longitudinal lung-function changes, and exacerbation risk. We analyzed data from the Korean Multicenter Bronchiectasis Audit and Research Collaboration (KMBARC), a prospective multicenter cohort of non-cystic fibrosis bronchiectasis. Patients were classified as having eosinophilia if blood eosinophil counts were ≥300 cells/μL at any point during a 3-year follow-up period. Baseline clinical, radiologic, pulmonary-function, symptom, and severity-index data were compared between patients with and without eosinophilia. Longitudinal changes in lung function and dyspnea were evaluated using mixed-effects models, and associations between eosinophilia and severe exacerbation outcomes were assessed using multivariable regression analyses. Among 832 patients, 158 (19.0%) demonstrated eosinophilia. Compared with patients without eosinophilia, those with eosinophilia showed greater radiologic extent, higher dyspnea scores, and higher baseline severity indices, including BSI, FACED, and E-FACED. Baseline FEV₁ (% predicted) was lower in the eosinophilia group; however, the rate of longitudinal FEV₁ decline over 3 years did not differ significantly between groups. In contrast, dyspnea severity worsened more prominently over time among patients with eosinophilia. Eosinophilia was associated with increased hospitalization risk in models without adjustment for disease severity, but this association was attenuated after adjustment for the Bronchiectasis Severity Index. Eosinophilia was not independently associated with emergency department visits. In conclusion, blood eosinophilia identifies a bronchiectasis subgroup with greater symptom burden and disease severity. However, eosinophilia was not independently associated with accelerated lung-function decline or severe exacerbation risk after adjustment for baseline disease severity.
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허혈-재관류에 의한 신장조직 손상에서 Cobalt Chloride의 조직 보호작용에 관한 연구
Brief ischemic periods before sustained ischemia known as ischemic preconditioning, have been shown to protect several organs, including the kidney, from ischemia-reperfusion( I-R ) injury. Cobalt chloride (COCL) has hypoxia-mimetic effects by inhibiting degradation of HIF-1α, which is a master regulator of genes activated by low oxygen tension. Herne oxygenase-1(HO-1), an inducible heat shock protein, is known to have cytoprotective effects against ischemic injury. This study evaluated the efficacy of COCL in a bilateral renal I-R injury model of male Sprague-Dawley rats. I-R renal injury was induced by 45 min clamping of both renal arteries. Rats in the sham(n=6) and I-R control groups(n=8) had been drinking tap water, whereas rats in the sham(n=6) and COCL treated I-R groups(n=9) had been drinking water containing 2 mM COCL from day -10 to day 1. The serum levels of creatinine, AST, LDH, and the renal tubular necrosis score based on light microscopic examination in each group were measured 24 hrs after surgery. The levels of renal gene expressions of HO-1, TGF-β, MCP-1, TNF-α, endeothelin-1, iNOS, Bcl-2 and Fas were measured by competitive RT-PCR. The serum level of creatinine 24 hrs after surgery was 2.6±1.1(mean±SD) mg/dL in I-R COCL treated group, significantly lower than that in I-R control group(4.8±1.6 mg/dL, p<0.05). The tubular necrosis score of I-R COCL treated group was also significantly lower than that of I-R control group(p<0.01). The renal gene expression of HO-1 was significantly upregulated in the COCL treated sham group compared to sham operated control rats. The HO-1 protein signal of kidney in the COCL treated I-R group measured by Western blot was also significantly higher than the level of I-R control group(p<0.05). The expressions of TGF-β, MCP-1, TNF-α, endothelin-1 and Fas genes in the kidneys of COCL treated I-R rats were significantly lower than those of I-R control rats(all, p<0.05). The level of Bcl-2 gene expression of kidneys in COCL treated I-R rats was significantly higher than the level of I-R control rats (p<0.05). In conclusion, it is speculated that the pretreatment of COCL in I-R injured rat model attenuates ischemic renal injury and at least in part, upregulation of renal HO-1 is involved in this mechanism.
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대전대학교 부속 한방병원에서 주로 암환자를 대상으로 면역력 증진을 목적으로 사용하고 있는 면역단의 구성성분인 노루궁뎅이버섯 추출물(WEHE)이 Yac1 cells에 대한 NK cells의 세포용해기능에 미치는 영향을 실험적으로 확인하여 다음과 같은 결론을 얻었다. 1. 노루궁뎅이버섯 추출물(WEHE)은 쥐 비장세포의 Yac1 cells에 대한 NK cells을 활성화하였다. 2. 노루궁뎅이버섯 추출물(WEHE)은 세포의 다른 면역매개체를 이용하여 NK cells을 활성화하였다. 3. 노루궁뎅이버섯 추출물(WEHE)은 antiIL12 antibody에 의하여 Yac1 cells의 세표용해기능이 감소되었으며, 이러한 결과는 IL12에 의해서만 WEHE가 유발한 NK cells의 세포용해기능이 활발해진다는 것을 암시한다. 4. 노루궁뎅이버섯 추출물(WEHE)은 쥐의 비장세표의 IL12 및IFNgamma proteins의 형질변환을 유도한다. 이상의 결과로 노루궁뎅이버섯(WEHE)은 IL-12의 성능발현을 자극하고, NK cell의 활성화를 통해 면역 조절과 항암제로서의 유용성이 기대되며 향후 이에 대한 지속적인 연구가 필요할 것으로 사료된다.
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한의학에서 숙지황은 신경계나 심혈관계 질환을 포함한 여러 질환을 치료하기위한 한약처방의 중요 구성성분의 하나로 사용되어왔다. 이번 연구에서는 백서의 손상된 척수신경 축삭에 대한 숙지황의 재생촉진효과에 대한 잠재적 가능성을 연구하였다. 숙지황의 투여는 손상부위보다 원위로의 축삭의 재생촉진에 효과적인 것으로 나타났다. 척수의 압박손상 14일 후, 식염수 처리군에 비해서 숙지황처리군의 Phospho-Erk1/2 단백질 양이 높게 유지되어있었다. Cdc2 단백질은 손상 후 손상된 척수부위에서 숙지황과 식염수 처리군에서 높게 유도되었다. Cdk2 양은 손상된 척수부위에서 식염수 처리군에서 증가되었고 숙지황 처리군에서 있어서 더욱 증가되었다. Cdk5 양에는 영향이 없었다. 숙지황 처리군은 식염수 처리군에 비해서 피질척수로 축삭의 손상된 부위를 지나는 수지상으로 뻗어나가는 것과 길이 성장을 강화하였다. 숙지황 처리군에서는 광범위한 신경섬유의 싹돌기 및 하향확장이 관찰되었다. 성상세포 배양결과 식염수 처리군과 비교해서 숙지황 처리군에서 세포의 증식과 개별 세포의 세포질 구조의 증가를 보였다. 손상 1개월 후 관찰에서 숙지황 처리군에서 손상부위의 glial scar의 형성이 식염수 처리군보다 좁은 영역에서 제한되었다. 손상 1 개월 후 Gridwalk test에서 식염수 처리군에 비해 숙지황 처리군에서 높은 점수를 기록하였다. 따라서 본 결과는 숙지황이 손상된 척수신경섬유의 재생물질로 응용될 수 있음을 암시한다.
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