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윤상임,송치운,이진홍,안미애,성기양,송민호,이강욱,신영태,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2
Major cardiovascular complications of diabetes are coronary atherosclerosis, diabetic dilated cardiomyopathy, autonomic neuropathy and those are major causes of morbidity and mortality in diabetic patients. Gated blood pool heart scan is noninvasive and useful method for evaluation of functional status of heart in diabetics. We evaluated 52 patients with diabetes and divided 3 groups. Group 1 were 11 patients without proteinuria or with proteinuria less than 550mng during 24 hours. Group 2 were 9 patients with proteinuria more than 550mg during 24 hours and group 3 were 32 patients with endstage renal diasese due to diabetes. We performed 99mTc-HSA cardiac gated blood pool scan and used left ventricular ejection fraction(LVEF), peak ejection rate(PEF) to indices of LV systolic function and peak filling rate(PER) to index of LV diastolic function. The results were follows : 1) LVEF, PER were significantly lower in diabetics with ESRD than diabetics without ESRD, but there were no significant difference between normal controls and diabetics without ESRD 2) PFR was significantly lower in diabetics than normal controls, but there were no significant differences in diabetics with or without nephropathy. 3) There were negative correlation between PER, PFR and duration of diabetes. On the basis of results, PFR is a LV functional index of GBPS which can disclose early change of LV dysfunction in patients with diabetes.
文九,林圭庠,崔賢 圓光大學校 漢醫科大學 1989 圓光漢醫大論文集 Vol.- No.6
After finding out cure-all method by analyzing and synthesizing of Peon-Zheng-Shi-Chi(辨證施治) and clinical character of peptic ulcer, forming a cure-all prescription, attempting to conform the modificatory method of Kun(monarch). Shin(minister). Zhoa(assistant). Sha(guide) of forming drugs by Peon-Zheng(辨證) and modificatory drugs with Peon-Zheng-Shi-Chi(辨證施治) of Oriental medicine and pharmacologic effect of Western medicine, the author obtained conclusion as below. 1. The cure-all method based on the method of Peon-Zheng-Shi-Chi(辨證施治) are So-Kan-Hai-Wul (疏肝解鬱), Hoa-Wei (和胃), Hoal-Heol-Sang-ki (活血生肌), Hai-Keong-Zhin-Tong (解痙鎭痛), Jhei-San(制酸)(antacid). 2. The forming drugs of cure-all prescripiton are Radix paeoniae, Radix Glycyrrhizae, Rhizoma Cyperi, Radix Aucklandiae, Radix Linderae, Rhizoma Atracyodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Os Sepiae, Rhizoma Corydalis, Resina Myrrhae, Radix Astragali, Radix Adenophorae, Ramulus Cinnamomi. 3. The main durgs of each Peon-Zheng(辨證) are Rhizoma Cyperi, Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Radix Aucklandiae, Radix Linderae in the symptoms of Ki-Chei(氣滯) Caused by Kan-Ki-Hoing-Yeog(肝氣橫逆) ; Radix Astrageli, Ramulus Cinnamomi, Radix Paeoniae Alba in the symptoms of Ki-Chei(氣滯) of Mog-Pul-So-To (木不疏土) caused by Kan-Ki-Her (肝氣虛) ; Radix Astragali, Ramulus Cinnamomi, Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Atractylodis Macrocephalae in the symptoms of Her-Han(虛寒);Radix Adenophorae, Radix Paeoniae Alba in the symptoms of Wei-Yeum-Her(胃陰虛) and Wul-Yeol(鬱熱) ; Rhizoma Cyperi, Rhizoma cotydalis, Resina Myrrhae in the symptoms of Yer-Heol(瘀血) ; Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis in the symptoms od Tam-Kuel(痰厥). On the other hand, classifying and using the modification and utility method by the character of drug in order to coinside with Peon-Zheng (辨證) and pharmacologic effect, and finding out the therapeutic methods and prescriptions to protect the sideaction, it is considered that the better therapeutic effect will gain.
Chelidonium majus-Induced Acute Hepatitis
Im, Sung Gyu,Yoo, Sun Hong,Jeon, Dong Ok,Cho, Hyo Jin,Choi, Jin Young,Paik, Soya,Park, Young Min Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1
The use of traditional folk remedies is increasing throughout Asia. Chelidonium majus, a popular herbal remedy, is used to treat abdominal pain caused by various gastrointestinal disorders, including gastric ulcer, gastritis, and biliary tract disease, because of its morphine-like effect. We encountered a 62-year-old woman with acute hepatitis, in which C. majus was suspected to be the etiological factor. The patient had taken high dose of C. majus extract for the preceding 60 days. The clinical context and the temporal association between the start of the herbal medicine treatment and her liver injury allowed us to attribute a causative role to C. majus. The diagnosis was confirmed by liver biopsy and the Council for International Organizations of Medical Sciences/Roussel Uclaf Causality Assessment Method (CIOMS/RUCAM) scale. After C. majus was discontinued, the liver function was restored to normal. In conclusion, because the use of phytotherapy is increasing, we wish to raise awareness of the potential adverse effects of C. majus.
Liver dysfunction induced by systemic hypersensitivity reaction to lamotrigine: case report
Sung Gyu Im,유선홍,Young Min Park,Sang Jin Lee,Sun Kyung Jang,Dong Ok Jeon,Hyo Jin Cho,Mi Jung Oh 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.2
Lamotrigine is an anticonvulsant drug used to treat partial and generalized seizure disorders. Hypersensitivity to lamotrigine usually causes mild symptoms such as fever, rash, and slight invasion of internal organs. However, a 33-year-old male patient who was admitted with Stevens-Johnson syndrome after taking lamotrigine for 15 days experienced hepatic failure and died 5 days after admission. This case demonstrates the importance of realizing that lamotrigine can lead to fatal hepatic failure, and that tests for the normal liver function should be performed when administering lamotrigine. (Clin Mol Hepatol 2015;21:180-182)

( Sung Gyu Im ),( Sun Hong Yoo ),( Young Min Park ),( Sang Jin Lee ),( Sun Kyung Jang ),( Dong Ok Jeon ),( Hyo Jin Cho ),( Mi Jung Oh ) 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.2
Lamotrigine is an anticonvulsant drug used to treat partial and generalized seizure disorders. Hypersensitivity to lamotrigine usually causes mild symptoms such as fever, rash, and slight invasion of internal organs. However, a 33 yearold male patient who was admitted with Stevens-Johnson syndrome after taking lamotrigine for 15 days experienced hepatic failure and died 5 days after admission. This case demonstrates the importance of realizing that lamotrigine can lead to fatal hepatic failure, and that tests for the normal liver function should be performed when administering lamotrigine. (Clin Mol Hepatol 2015;21:180-182)
林盛奎(Im Sung-Gyu) 한국일본문화학회 2002 日本文化學報 Vol.12 No.-
1893년(명치26) 2월, 도오손은 17세부터 22세까지 5년 간 계속된 신앙생활에서 발을 뺀다. 연보에 “느끼는 점이 있어서 기독교회로부터 탈퇴하다”라고 기록하고 있지만, 그 후 도오손이 교회에 복귀한 기록은 없다. 많은 평자는 이 일을 “크리스트교 절대신 에서 범신론적 자연”에 이행하였다고 말하고, 혹은 “프로테스탄티즘에서 휴머니즘”에 또는 “미적 신 추구, 문학”에 라고 말하지만, 단순하게 작품 속에서 그런 경향이 보였다하더라도 후에 도오손 문학에 감도는 무거운 우울의 기분은 어떻게 설명하여야 할 것인가? 청춘의 우울이라는 언어가 있다고는 하더라도 간단하게 정리할 수는 없을 것이다. 信州인 독특한 기질에서 오는 것도 있고, 유전적인 것이라고도 생각할 수 있지만 도오손 자신의 내적 투쟁의 격렬함에 유래한다고 보아도 좋지 않을까? 그가 작품 속에서 보이는 성서의 이해는 정통적 신앙을 일탈하고 있지 않다. 『破戒』 전후의 여러 가지 도오손을 엄습한 사건도 도오손으로 하여금 감추어진 신앙은 깊어질지언정 소멸하지는 않았다. 그러나, 보다 강하게 크리스트교를 의식한 것은, 탈출한 것 같이하여 유학한 프랑스에서의 경험이었다. 이 프랑스 체험이 도오손에게 재생의 계기를 마련해준 것은 주지의 사실이다. 이 프랑스에서의 체험이 도오손에게 〈신생〉의 동기를 부여한다. 도오손은 책에 줄을 긋는 습관이 있어, 특히 주의해야하는 중요한 부분이나 관심이 있는 부분 등에는 파란 연필로 밑줄을 그었다고 한다. 이토카즈오의 보고에 의하면, 도오손이 부인과 공유한 미국 성서협력회발행의 신약성서 에서, 도오손은 「로마서」에서 「디모데서」 사이의 서간서에 파란 연필로 밑줄을 많이 쳤다고 한다. 이 사실은 주로 도오손이 죄에서부터의 재생에 대하여 깊은 관심을 갖고 있었던 것을 말한다. On February of 1893, Dawson departed from his five year's religious life. According to the report of a chronological record, his departure seems to be temporary, but there is no sign of his returning to the Christianity. Critics interpreted this action in many ways: a transition from the absolute God to pantheistic nature, from Protestantism to Humanism, or even chasing aesthetic God. These trends might be illustrated in his work in part, but one needs to fully understand about the heavy mood of Dawson's literature. The word “the gloominess of youth" is not enough in explaining his work. It could be from the unique nature of the Christian belief, hereditary factors, or even his own struggle with his inner self. In his work, he followed the traditional Christian doctrine. However, what made him a real christian was form his experience in France where he studied abroad. It is a widely known fact that this experience offered him a rebirth. While reading, Dawson had a habit of drawing lines under the meaningful sentences. According to Itokazo's report, in the New Testament which he shared with his wife, Dawson drew many lines between Romans and Timothy. This fact strongly supports the claim that Dawson had a very keen interest toward the rebirth from the sin.
