양극성장애와 새로운 항경련제의 효과

남범우,서정석,정헌종,최진영 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.13 No.-

Bipolar disorder, like epilepsy and migraine, is episodic in nature and psychiatric illness requiring lifelong treatment. So, it should not be surprising that anticonvulsants such as carbamazepine and valproate have proven efficacy as mood stabilizers. The newer anticonvulsants such as lamotrigine, gabapentin, topiramate, oxcarbazepine, tiagabine, and zonisamide may also be effective treatments for bipolar disorder. Identifying an anticonvulsant for use in bipolar disorder should take into account not only the pathophysiology of bipolar disorder but also the mechanism of action of the anticonvulsant. Evidence for effectiveness of these novel antiepileptic drugs in treating acute mania and depression as well as in preventing the recurrence of mania and depression is reviewed. In conclusion, although the novel anticonvulsants appear to be clinically useful, more controlled trials are needed to assess the effectiveness in bipolar disorder.

VDT작업별 정신사회적 스트레스와 근골격계 장애에 관한 연구

백남종,강종두,주영수,배인근,권호장,박종만,조수헌,김돈규,김재용,최홍렬 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.4

It has been hypothesized that jobs that have both high psychological demands and low decision latitude("job strain") can lead to musculoskeletal disorder. The objective of this study was to test whether job strain was correlated with the presence of work-related musculoskeletal disorder, especially myofascial pain syndrome(MPS). Information on demographic factors, confounders such as household load and taking care of children or not, and scores for decision latitude, job demand, and social support was obtained by self-administered questionnaire, which had been developed in Korean language, by adopting NIOSH instrument and Extended Karasek Model(16 items). All subjects were also examined by rehabilitation medicine specialists for musculoskeletal disorders. Subjects(n=370) could be categorized into 4 groups, these were, housewives(n=89), shipyard CAD workers(n=89), general female workers(n=79; nurses, insurance counselors, public officials, clerks, etc), and telephone directory assistance operators(n=113). Results from univariate analyses indicated that all demographic factors, all confounders, scores for decision latitude and social support were not associated with the risk of musculoskeletal disorder. However, score for job demand was higher in musculoskeletal disorder cases than others. In subgroup analysis, this association was convinced again, in telephone directory assistance operators. Job strain model showed that the group of telephone directory assistance operators was high-stain group, and OR of musculo skeletal disorder was 2.446(95% C. I. : 1.174, 5.096), when comparing this with the low strain group. In conclusion, job strain is a risk factor for work-related musculoskeletal disorder.

방사선 조사를 받은 흰쥐 신경뇌하수체 관문의 미세구조 : 관문의 새로운 개념설정 Establishment of a New Concept on the Barrier

이헌용,안의태,양남길,고정식,박경호 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

신경뇌하수체는 뇌의 일부지만 뇌실둘레기관(circumventricular organ)으로서 전형적인 혈액-뇌관문이 없으므로 혈관 안팎의 물질이동이 자유로운 신경내분비기관이다. 이 실험에서는 심한 방사선 조사시에 혈액-신경뇌하수체관문의 형태적 대응을-연구함으로써, 관문의 특성을 분석했으며, 관문의 구성을 구체적으로 설정하여 이를 개념화 할 것을 제안하였다. 체중 200-250g의 숫흰쥐를 sodium thiopenthal 로 마취시킨 후 Mitsubishi선형가속기로 방사선 조사를 시켰다. 조사조건은 거리 80cm, 조사구역 30 X 30cm, 조사깊이 1.2cm, 조사속도 분당 200 rads로 하여 실험군에 따라 3,000 rads 또는 6,000 rads가 되도록 했다. 조사후 6시간, 2일, 6일후에 각군의 동물을 도살 하여 신경뇌하수체를 떼어냈다. 떼어낸 조직은 1% glutaradehyde- 1% paraformaldehyde액에 1차 고정하고, 1% osmium tetroxide액에 2차 고정하였고, araldine혼합액에 포매된 조직은 절편을 만들어 uranyl acetate와 lead citrate액으로 염색해서 전자현미경으로 관찰하였다. 주로 모세혈관주위공간에서 관문구조를 중심으로 관찰한 결과 3,000 rads 조사군과 6,000 rads조사군 모두가 비슷하게 심한 변화를 보였고, 변화의 정도가 2일군에서 가장 심했으며 6일군에서는 약간 안정되는 모습이었으나 변화의 양상은 모든 실험군을 통해서 비슷하였다. 가장 두드러진 변화는 모세혈관주위공간에서 나타났는데 공간의 확장, 큰포식세포의 증가와 활성화, 신경뇌하수체세포속에 들어 있던 신경종말들의 이탈, 먼지 같은 물질의 증가 등을 들 수 있었다. 특히 큰 포식세포의 변화는 매우 특징적이어서 넓은 세포질관(판상족, lamellipoda)을 형성하여 모세혈관과 신경뇌하수체세포사이를 차단시킬 뿐아니라 왕성한 포식작용으로 공간내의 축삭종말들을 용해시켰다. 큰포식세포의 세포질안에는 과립형질내세망들이 매우 발달하였고, 세포질 영역이 매우 넓어진 것으로 볼 때, 이들이 기동타격대로서 활발히 움직이는 매우 효율적인 관문의 구성성분으로 생각되었다. 특히 신경뇌하수체는 전형적인 혈액-뇌관문이 없으므로 신경내분비기능의 수행에는 유리하나 면역활성물질이나 독성물질등 뇌에 해로운 물질의 왕래를 차단하여 제거하거나, 과다하게 분비된 신경호르몬을 조절하는 일이 중요하다고 볼 때, 큰포식세포가 이같은 역할에 적합한 구성성분이라는 결론을 얻었다. 이 실험에서는 효율성이 높은 관문으로서 혈액-신경뇌하수체관문이 구성성분을 차례로 기재하고 이를 개념화 할 것을 제안한다. 모세혈관과 축삭종말사이에 형성되어 있는 혈액-신경뇌하수체관문이 구성을 차례로 표기하면 다음과 같다 (그림 9,10). 1. 유창모세혈관 내피 2. 모세혈관 내피의 기저판 3. 혈관주위세포와 기저판("이차방어선", 한정된 범위내에서 움직일 수 있다). 4. 큰포식세포, 필요에 따라 판상족(lamellipoda)을 넓게 뻗는다.("삼차방어선", 모세혈관 주위공간 속을 이동해 다니는 "기동타격대") 5. 신경뇌하수체세포의 기저판 6. 신경뇌하수체세포의 세포질돌기(호르몬분비 조절) To study the morphological characteristics of the blood-neurohypophysis barrier system in a severely altered situation, the heads of rats were exposed to heavy X-irradiation. Rats weighing 200-250 g each were anesthetized with sodium thiopenthal, and placed on the table of Mitsubishi linear accelerator ML-4MV. Only heads of rats were placed within the exposure area of 30 cm X 30 cm. Irradiation was processed at the distance of 80 cm, with the speed of 200 rads/min in the radiation depth of 1.2cm. Total doses were 3,000 rads or 6,000 rads according to the animals of the different experimental groups. Rats were sacrificed on 6 hours, 2 days or 6 days following radiations. Tissue blocks of neurohypophyses were fixed in the 1% glutaraldehyde-1% paraformaldehyde solution, and they were refixed in the 1% osmium tetroxide solution. Ultrathin sections were contrasted with uranyl acetate and lead citrate solutions. Electron micrographs exhibited dramatic changes within the perivascular space of neurohypopysis. The perivascular space was greatly enlarged, and it contained many macrophages, floating axonal endings and plentiful flocculent materials. The enlargement was largest in the 2 day-group animals. Many macrophages are activated, and it showed tremendous cytoplasmic lamellipoda. Wide plate of macrophagic cytoplasm usually engulfed the floating axon terminals, and are located between the cappillary and the pituicytes. The situation gave the impression that macrophages prevent, filter and/or retrieve the excessive materials transported between the capillary and the axonal endings. Since the perivascular microenvironment of neurohypophysis is more vulnerable as compared with those brain areas equipped with blood-brain barrier, the functional barrier system by macrophages in the neurohypophysis should have important role. The concept of blood-neurohypophyseal barrier with the following components is proposed. The components of the barrier system from the blood pool to the hormonal pool are 1. Endothelium of fenestrated capillary 2. BAsal lamina of endothelium 3. Pericyte("second line of defense". mobile in a limited area) 4. Macrophage, extending its wide cytoplasmic plate(the lamelipoda) in need("third line of defense". freely movable in the perivascular space, "active surveillance system") 5. Basal lamina of pituicyte 6. Cytoplasmic processes of pituicyte

一樣有界原理에 관한 槪觀

金憲男,黃洪澤 金烏工科大學校 産業技術開發硏究院 1999 産業技術開發硏究 Vol.15 No.-

1932년 바나하에 의해 소개된 一樣有界元理(Uniform boundedness Principle)는 베어 카테고리 定理를 이용하여 證明 되었으며, 대부분 문헌 역시 같은 방법으로 소개하고 있다. 본 논문은 베어카테고리 정리와는 관계없는 초보적인 보조정리를 이용한 一樣有界元理 證明을 소개 한다. 나아가 一樣有界元理를 응용하여 얻은 기존의 결과들을 재 조명함으로써, 동 원리를 응용할 수 있는 수학적 대상을 탐색하고 활용하는 데에 도움을 주고자 한다.

바람의 영향을 고려한 제주항의 유동해석

김남형,박지훈 濟州大學校 海洋硏究所 2003 해양과환경연구소 연구논문집 Vol.27 No.-

The effect of wind on the circulation in Jeju harbor was examined using a numerical shallow water model. A finite element for analyzing shallow water flow is presented. The Galerkin method is employed for spatial discretization. Two step explicit finite element scheme is used to discretize the time function. which has advantage in problems treating large numbers of elements and unsteady state. The experiments compare the case considering the effect of wind with the case which do not consider the wind effect. According to wind direction NW winds. velocity of flow vector became slightly stronger in the flow field. The computed results have shown the good adaptability of moving boundary condition and effect of wind. From these studies. it can be concluded that the present method is a useful and effective tool in tidal current analysis.

고무의 산화방지제인 N-(1,3-dimethylbuthyl)-N'-phenyl- p-phenylene-diamine의 제조 및 특성

변헌수,전남석 여수대학교 1998 論文集 Vol.13 No.2

We were studied to the preparation and the study of property of N-(1.3-dimethyl-butyl)-N'-phenyl-p-phenylene-diamine from diphenylamine by the various synthetic methods : nitrosoation, rearrangement, hydrogenation and reductive alkylation. In this study, we were obtained to the optimum conditions of reaction step and applied the obtained data in Lab. to plant. The data of Lab. test were as follows : the purity of p-amino-diphenylamine from diphenylamine was 97.0% and the yield of p-amino-diphenyl-amine from diphenylamine was 88.0%, the purity of N-(1.3-dimethylbutyl)-N'-phenyl-p-phenylene-diamine from diphenyl-amine was 98.5% and the yield of N-(1.3-dimethylbutyl)-N'-phenyl-p-phenylene-diamine from dipheny-lamine was 98.0%.

대전 3ㆍ4 산업단지 주변의 하천수 및 지하수오염 실태조사

조남운,김태응,손동훈,임봉수 대전대학교 산업기술연구소 2000 산업기술연구소 論文集 Vol.11 No.2

The purpose of this study is to investigate the quality of surface water and groundwater near the Daejeon 3.4 industrial complex. In the case of surface water quality as considered by BOD, the water quality of the Hyun-do Bridge in Kum river was suitable to the class II (less than 3mg/L) of environmental standard for the river. The water quality of Bool-lo Dong in Kum river after joins Kab stream was class III (less than 6mg/L) and the water quality of Kab-chun Bridge was over class V as over about 8mg/L(less than 10mg/L). In the result for the groundwater at Wit-mal, the NO3-N concentration was average 14.6mg/L and maximum 23.4mg/L that was about twice more than the drinking water quality standard regulations(10mg/L). In other points, the groundwater quality was inadequate to the standard for a few items.

만성 화농성 중이염의 세균학적 고찰

조남순,이영훈,강기훈,최제환,송태현,이병돈,장혁순,강주원,김연준 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Background and Objectives : Chronic suppurative otitis media is one of the frequent diseases in otolaryngologic field. It is important to choose of antibiotics in the management of infectious disease. But the organisms in infections have been changed and resistance to antibiotics has been grown as the development of antibiotics has been achieved. And so it has been necessary to recognize the changes of organisms and resistance in antibiotics. Our study was performed to identify the pathogens isolated from discharges in chronic otitis media and evaluate the antibiotic agents, to recognize the change of to resistance to·antibiotic agents and to use the appropriate anitiotics. Materials and Methods : Retrospectively, authors reviewed the backeriologic study of 114 cases of chronic suppurative otitis media who visited the Department of Otolaryngology, Soonchunhyang University in Seoul from Nov. 1996 to Oct. 1999 and analyzed 101 strains and its sensitivity test to various antibiotics. Result : In 93 cases in which pathogenic organism was isolated, single infection was 85 cases(91.4%) and mixed infection was 8 cases(8.6%). The most frequent pathogenic organism was Staphylococcus aureus(59.4%), Pseudomonas aeruginosa(13.9%), Providencia(4.8%), Alcaligenes(3.0%) and Streptococcus pneumoniae(2.9%) were the next. Methicilline-Resistance Staphylococcus aureus was 34 cases(57.6%) of Staphylococcus aureus. Staphylococcus aureus was sensitive to Vancomycin(96.7%), Trimethoprim-Sulfamethoxazole (57.6%), Cefuroxime(42.4%) and Ciprofloxacin(40.7%) but resistant to Penicillin(94.9%). Pseudomonas aeruginosa was sentitive Amikacin(100%), Ciprofloxacin(100%) and Gentamicin(67%). Conclusion : As MRSA recently was wide spread in community accquired infection as well as nosocomial infection, we must consider strict control of MRSA.

외측 미칩 갑상선에서 발생하여 다발성 전이로 발현된 유두상 갑상선암 1예

천남일,이창훈,홍세인,정진욱,윤인석,조동혁,강호철,정동진,정민영 대한내분비학회 2001 Endocrinology and metabolism Vol.16 No.4-5

올레산의 비율에 따른 아데노신의 경피 투과의 영향

남현빈,정세진,구민석,오예진,김용민,이훈희,윤수정,임정균 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

In addition to the development of functional cosmetics, technology to increase percutaneous absorption rate when applied to the skin is an important task. In this experiment, oleic acid was used as a skin absorption promoter, and its effect on transdermal permeability of adenosine was studied and analyzed using a skin-like membrane. As a result of the experiment, it was investigated that the permeability coefficient and concentration of adenosine are proportional to the content of oleic acid. This indicates that a high proportion of oleic acid is effective as a skin absorption promoter.