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    • KCI등재

      Taking Real Wage Rigidities Seriously: Implications for Optimal Policy Design in a Currency Union

      Lenard Lieb 한국국제경제학회 2012 International Economic Journal Vol.26 No.1

      This paper analyzes optimal monetary and fiscal policy in a monetary union from a union-wide perspective, using a multi-country New Keynesian business-cycle model with rigid real wages. Fiscal policy is implemented at the country level through decisions regarding government spending, while the monetary authority sets a common nominal interest rate. It is found that in the presence of country-specific shocks as well as symmetric shocks, there is a country-level trade-off between stabilizing inflation and the output gap. After a union-wide shock, the common monetary authority also faces a trade-off. If shocks are symmetric, the optimal union-wide policy requires that the common central bank conduct a countercyclical policy, allowing for more relative inflation volatility than the amount actually allowed by the ECB. The role of policies is reversed at the domestic level, where the government stabilizes the economy via a countercyclical policy, regardless of whether shocks are symmetric.

    • SCIESCOPUSKCI등재

      review : Advent of Novel Phosphatidylcholine-Associated Nonsteroidal Anti-Inflammatory Drugs with Improved Gastrointestinal Safety

      ( Yun Jeong Lim ),( Elizabeth J Dial ),( Lenard M Lichtenberger ) 대한소화기학회 2013 Gut and Liver Vol.7 No.1

      The mucosa of the gastrointestinal (GI) tract exhibits hydrophobic, nonwettable properties that protect the underlying epithelium from gastric acid and other luminal toxins. These biophysical characteristics appear to be attributable to the presence of an extracellular lining of surfactant-like phospholipids on the luminal aspects of the mucus gel layer. Phosphatidylcholine (PC) represents the most abundant and surface-active form of gastric phospholipids. PC protected experimental rats from a number of ulcerogenic agents and/ or conditions including nonsteroidal anti-inflammatory drugs (NSAIDs), which are chemically associated with PC. Moreover, preassociating a number of the NSAIDs with exogenous PC prevented a decrease in the hydrophobic characteristics of the mucus gel layer and protected rats against the injurious GI side effects of NSAIDs while enhancing and/or maintaining their therapeutic activity. Bile plays an important role in the ability of NSAIDs to induce small intestinal injury. NSAIDs are rapidly absorbed from the GI tract and, in many cases, undergo enterohepatic circulation. Thus, NSAIDs with extensive enterohepatic cycling are more toxic to the GI tract and are capable of attenuating the surface hydrophobic properties of the mucosa of the lower GI tract. Biliary PC plays an essential role in the detoxification of bile salt micelles. NSAIDs that are secreted into the bile injure the intestinal mucosa via their ability to chemically associate with PC, which forms toxic mixed micelles and limits the concentration of biliary PC available to interact with and detoxify bile salts. We have worked to develop a family of PC-associated NSAIDs that appear to have improved GI safety profiles with equivalent or better therapeutic efficacy in both rodent model systems and pilot clinical trials. (Gut Liver 2013;7:7-15)

    • SCISCIESCOPUS

      CCM key comparison CCM.D-K4 'Hydrometer'

      Lorefice, S,Becerra, L O,Lenard, E,Lee, Y J,Lee, W G,Madec, T,Meury, P A,Caceres, J,Santos, C,Vamossy, C,Man, J,Fen, K,Toda, K,Wright, J,Bettin, H,Toth, H BUREAU INTERNATIONAL DES POIDS ET MESURES 2016 METROLOGIA -BERLIN- Vol.53 No.-

      <P></P> <P>This report presents the comparison philosophy, methodology, analysis and the results of the designed CCM.D-K4 key comparison that covered the calibration of high resolution hydrometers for liquid and alcoholometers in the density range 600 kg/m<SUP>3</SUP> to 2000 kg/m<SUP>3</SUP> at the temperature of 20°C. The main purpose of this comparison was not only to evaluate the degree of equivalence in the calibration of high accuracy hydrometers between NMI participants, but also to link, were it is possible, the results of previous comparisons to Key Comparison Reference Values (KCRVs) of CCM.D-K4. Eleven NMI laboratories took part in the CCM.D-K4 divided in two groups (petals).</P> <P>With the CCM.D-K4 purpose, two similar sets consisting of three hydrometers for liquid density determinations and an alcoholometer were circulated to the NMI participants as a travelling standard in the time interval from January 2011 to April 2012.</P> <P>Twelve Key Comparison Reference Values (KCRVs) for each petal have been obtained at the density values related to the tested density marks of the transfer standards by the results of participants. The KCRVs and corresponding uncertainties were calculated by the weighted mean in the case of consistent results, otherwise the median was used.</P> <P>The degree of equivalence (DoE) with respect to the corresponding KCRV was determined for each participant and, in this particular comparison, the Weighted Least Squares (WLS) method was used to link the individual DoE of each participant by a continuous function.</P> <P>Significant drift of the transfer standards was not detected.</P> <P>This report also gives instructions on calculating pair-wise degrees of equivalence, with the addition of any information on correlations that may be necessary to estimate more accurately as well as the procedure for linking international comparisons to the CCM.D-K4. Finally an example of linkage to the CCM.D-K4 is given by dealing with the results of the bilateral comparison between INRiM and NMIA, which was added to this comparison so that all participants were engaged after the breakage of the 9340171 artefact.</P> <P>A particularly good agreement was found among the results provided by most of the participants, even if some systematic differences and either underestimated or overestimated uncertainties of the submitted results can be identified with respect to the KCRVs. In general the deviations of the laboratory results to the KCRVs are within of 1/3rd to 1/4th of a scale division and the uncertainty at 95% is usually within half a division. During the analysis of the submitted results, a systematic difference between the first and last immersed mark was also noted, possibly due to a temperature gradient along the stem and/or wetting of the stem around the tested mark, and therefore a corrected claimed uncertainty from each laboratory is expected. However this comparison may help the laboratories to solve some residual or marginal problems as well as to better understand the uncertainty components.</P> <P>The comparison fully supports the calibration measurement capabilities table in the BIPM key comparison database (KCDB). The results can be used to link regional comparisons to this CCM key comparison</P> <H2>Main text</H2> <P> To reach the main text of this paper, click on <A HREF='http://www.bipm.org/utils/common/pdf/final_reports/M/D-K4/CCM.D-K4_Final_Report.pdf'>Final Report</A>. Note that this text is that which appears in Appendix B of the BIPM key comparison database <A HREF='http://kcdb.bipm.org/'>kcdb.bipm.org/</A>.</P> <P>The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).</P>

    • SCOPUSKCI등재

      신경망을 이용한 HSLA 강의 고온 유동응력 예측 및 통계방법과의 비교

      Chun, Myung-Sik,Yi, Joon-Jeong,Jalal, B.,Lenard, J.G. 대한기계학회 1997 大韓機械學會論文集A Vol.21 No.5

      The knowledge of material stress-strain behavior is an essential requirement for design and analysis of deformation processes. Empirical stress-strain relationship and constitutive equations describing material behavior during deformation are being widely used, despite suffering some drawbacks in terms of ease of development, accuracy and speed. In the present study, back-propagation neural networks are used to model and predict the flow stresses of a HSLA steel under conditions of constant strain, strain rate and temperature. The performance of the network model is comparedto those of statistical models on rate equations. Well-trained network model provides fast and accurate results, making it superior to statistical models.

    • 신경망을 이용한 HSLA 강의 고온 유동응력 예측 및 통계방법과의 비교

      Chun, Myung-Sik,Yi, Joon-Jeong,Jalal, B.,Lenard, J.G. 대한기계학회 1997 대한기계학회논문집 Vol.21 No.5

      The knowledge of material stress-strain behavior is an essential requirement for design and analysis of deformation processes. Empirical stress-strain relationship and constitutive equations describing material behavior during deformation are being widely used, despite suffering some drawbacks in terms of ease of development, accuracy and speed. In the present study, back-propagation neural networks are used to model and predict the flow stresses of a HSLA steel under conditions of constant strain, strain rate and temperature. The performance of the network model is comparedto those of statistical models on rate equations. Well-trained network model provides fast and accurate results, making it superior to statistical models.

    • KCI등재

      Comparison of virtual and in-person simulations for sepsis and trauma resuscitation training in Singapore: a randomized controlled trial

      Matthew Jian Wen Low,Gene Wai Han Chan,Zisheng Li,Yiwen Koh,Chi Loong Jen,Zi Yao Lee,Lenard Tai Win Cheng 한국보건의료인국가시험원 2024 보건의료교육평가 Vol.21 No.-

      Purpose This study aimed to compare cognitive, non-cognitive, and overall learning outcomes for sepsis and trauma resuscitation skills in novices with virtual patient simulation (VPS) versus in-person simulation (IPS). Methods A randomized controlled trial was conducted on junior doctors in 1 emergency department from January to December 2022, comparing 70 minutes of VPS (n=19) versus IPS (n=21) in sepsis and trauma resuscitation. Using the nominal group technique, we created skills assessment checklists and determined Bloom’s taxonomy domains for each checklist item. Two blinded raters observed participants leading 1 sepsis and 1 trauma resuscitation simulation. Satisfaction was measured using the Student Satisfaction with Learning Scale (SSLS). The SSLS and checklist scores were analyzed using the Wilcoxon rank sum test and 2-tailed t-test respectively. Results For sepsis, there was no significant difference between VPS and IPS in overall scores (2.0; 95% confidence interval [CI], -1.4 to 5.4; Cohen’s d=0.38), as well as in items that were cognitive (1.1; 95% CI, -1.5 to 3.7) and not only cognitive (0.9; 95% CI, -0.4 to 2.2). Likewise, for trauma, there was no significant difference in overall scores (-0.9; 95% CI, -4.1 to 2.3; Cohen’s d=0.19), as well as in items that were cognitive (-0.3; 95% CI, -2.8 to 2.1) and not only cognitive (-0.6; 95% CI, -2.4 to 1.3). The median SSLS scores were lower with VPS than with IPS (-3.0; 95% CI, -1.0 to -5.0). Conclusion For novices, there were no major differences in overall and non-cognitive learning outcomes for sepsis and trauma resuscitation between VPS and IPS. Learners were more satisfied with IPS than with VPS (clinicaltrials.gov identifier: NCT05201950).

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