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글루타메이트에 의한 산화적 스트레스로 유도된 인체 신경세포 SH-SY5Y 모델에서 길초근 추출물의 수면개선 효과
김정은 ( Jung Eun Kim1¸ Tae-su Kim2¸ Bo-ram Kim3¸ Su Hui Seong3¸ Jin-ho Kim3¸ Ha-nul Lee3¸ Chan Seo3¸ Hwa Lee3¸ Su A Im1¸ Ji Min Jung1¸ Kyung-min Choi4 ),김태수 ( And Jin-woo Jeong5* ),김보람,성수희,김진호,이하늘,서찬,이화 한국자원식물학회 2024 한국자원식물학회 추계학술대회 자료집 Vol.2024 No.0
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Thiocholine ester 기질을 이용한 Acetylcholinesterase 활성부위의 구조특성
이천배,주은희,최수라,석대은,명평근 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
The inhibition pattern of three inhibitors(tacrine, decamethonium and propidium) on the hydrolysis of various thiocholine ester substrates by eel acetylcholinesterase was comparatively examined. When the substrate was acetylthiocholine, it showed a similar competitive inhibition by tacrine inhibitor, and a mixed type inhibition by decamethonium and propidium inhibitors. When the substrate was pentanoylthiocholine, it showed an uncompetitive inhibition by tacrine, and a noncompetitive inhibition by decamethonium. When the substrate was laurylthiocholine, it showed mixed type and uncompetitive inhibition by tacrine, and a competitive inhibition by decamethonium and propidium. Those results suggest that the active of acetylcholinesterase has the existence of hydorphobic site besides the anionic and esteratic site.
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식이 단백질의 급원에 따른 당뇨쥐의 혈당 및 혈청지질에 미치는 영향
이수진,김영진,박수정,김희정,이윤희,유영상 동아시아식생활학회 1997 동아시아식생활학회지 Vol.7 No.2
This study was designed to find out the effects of soybean protein and milk protein between nondiabetic and diabetic rats. The experimental results are summarized as follows. 1. Total food intake was higher in diabetic soybean protein group than other groups but it was not significant. 2. The change of body weight was lower in diabetic soybean protein group than other groups and the soybean protein was effective to maintain the ideal body weight. 3. The effects of lowering total cholesterol and glucose in serum was higher in soybean protein groups than the milk protein groups.
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Thiocholine ester 기질을 이용한 Acetylcholinesterase 활성부위의 구조특성
이천배,주은희,최수라,석대은,명평근 충남대학교 기초과학연구소 1999 忠南科學硏究誌 Vol.26 No.1
The inhibition pattern of three inhibitors(tacrine, decamethonium and propidium) on the hydrolysis of various thiocholine ester substrates by eel acetylcholinesterase was comparatively examined. When the substrate was acetylthiocholine, it showed a similar competitive inhibition by tacrine inhibitor, and a mixed type inhibition by decamethonium and propidium inhibitors. When the substrate was pentanoylthiocholine, it showed an uncompetitive inhibition by tacrine, and a noncompetitive inhibition by decamethonium. When the substrate was laurylthiocholine, it showed mixed type and uncompetitive inhibition by tacrine, and a competitive inhibition by decamethonium and propidium. Those results suggest that the active site of acetylcholinesterase has the existence of hydrophobic site besides the anionic and esteratic site.
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내독소로 유도되는 Nuclear Factor Kappa B 활성화에 미치는 Src Family Kinase의 조절기전
김희재,이혜원,이희수,하종식,이지희 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2
목적: Src family tyrosine kinases (TK)가 내독소로 인해 유도되는 NF-kB 활성화 신호전달체계에 연관되어 있음이 보고된 바 있다. 또한 내독소(LPS)나 TNF a와 같은 여러 자극제는 IkB-a 의 serine기 또는 tyrosine기의 인산화를 통하여 NF-kB를 활성화 시킨다고 알려진 바 있다. 이에 본 연구에서는 RAW 264.7 대식세포에 내독소 투여 시 유도되는 NF-kB활성화 및 NF-kB 의존성 염증성인자 생성에 대한 Src TK의 역할에 대해 규명하고자 한다. 방법: American Type Culture Collection 에서 구입한 생쥐의 대식세포, RAW264.를 내독소(LPS)에 노출시킨 후 damnacanthal나 PP1을 처리하여, EMSA, Nitrite assay, Western blot을 통하여Src TK가 NF-kB활성과 염증인자의 생성에 있어서 어떤 역할을 하는지에 대하여 조사하였고 내독소 투여로 인한 NF-kB활성에 있어서 Src TK의 기본적인 작용기전에 대해 조사하였다. 결과: Damnacanthal이나 PP1은 Src TK 특이적 억제제로 알려져 있는데, 본 연구에서는 Src TK의 특이적 억제제인 damnacanthal 이나 PP1을 사용하였고, RAW 264.7 대식세포에서 Src TK 특이 억제제의 전처치는 내독소로 유도되는 NF-kB활성을 차단시켰다. 또한 내독소 투여로 증가된 NO 생성은 damnacanthal이나 PP1에 의하여 억제되었다. 이런 TK kinase 억제제는 내독소로 유도되는 serine 기 인산화와 IkB-a 분해를 억제시켰다. 결론: Src kinase 특이적 억제제인 damnacanthal 그리고 PP1이 RAW 264.7세포에서 내독소로 유도되는 NF-kB활성과 Nitric Oxide 생성을 차단시켰다. 또한. Damna-canthal이나 PP1은 내독소로 유도된 serine기 인산화와 IkB-a의 분해를 억제시켰다. Objectives : Src family tyrosine kinases(TK) have been found to be involved in LPS induc-tion of signal cascades. Furthermore Lipopolysaccharide(LPS) or Tumor necrosis factor alpha (TNF-a) activate nuclear transcription factor kB(NF-kB) by inducing serine or tyrosine pho-sphorylation of the inhibitory subunit of NF-k B(I k B- a). In this study, it is our purpose to search the role of Src TK in LPS induced activation of NF-k B and NF-k B dependent induced inflam-matory factors. Methods : Nuclear extracts were prepared from RAW 264.7 cells pretreated with damnacan-thal or PP1 and then stimulate with LPS. After that, we figured out the dffects of inhibition of Src family kinases on LPS-induced activation of NF-kB by EMSA. We investigated effects of damnacanthal of PP1 on the production of NO by Griess assay and LPS-induced serine phos-phorylation and degradation of Ik B-a by Western blots in LPS-stimulated RAW263.7 cells. Results : Inhibition of Src TK with damnacanthal or PP1 blocked LPS-induced NF-kB acti-vation at the range of nanomolar concentrations. Substantial inhibition in LPS-induced production of NO was also observed in cells treated with damnacanthal or PP1. These kinase inhibitors blocked LPS-induced the serine phosphorylation, and the degradation of Ik B-a. Conclusion : we investigated the role of Src TK in NF-k B activation and production of nitric oxide (NO) in LPS stimulated RAW 264.7 macrophages and the underlying mechanism by which Src TK play a role in LPS-induction of the possible pathways leading to NF-k B activation. Src kinase specific inhibitors, damnacanthal and PP1 blocked LPS induced activating NF-k B and producing Nitric Oxide in Raw 264.7 machrophages. Moreover, Damnacanthal and PP1 inhibited LPS induced serine phosphorylation and degradation of Ik B-a.
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X-band Linac for a 6MeV dual-head radiation therapy gantry
Lee, Seung Hyun,Shin, Seung-Wook,Lee, Jongchul,Kim, Hui-Su,Lee, Byeong-No,Lee, Byung-Chul,Park, Hyung-dal,Song, Ki-back,Song, Ho-seung,Mun, Sangchul,Ha, Donghyup,Chai, Jong-Seo Elsevier 2017 Nuclear Instruments & Methods in Physics Research. Vol.852 No.-
<P><B>Abstract</B></P> <P>We developed a design for a 6MeV X-band linear accelerator for radiation therapy in a dual-head gantry layout. The dual-head gantry has two linacs that can be operated independently. Each X-band linac accelerates electron bunches using high-power RF and generates X-rays for radiation therapy. It requires a versatile RF system and pulse sequence to accomplish various radiation therapy procedures.</P> <P>The RF system consists of 9.3GHz, 2MW X-band magnetron and associated RF transmission components. A test linac was assembled and operated to characterize its RF performance without beam. This paper presents these results along with a description of the gantry linacs and their operational requirements.</P>
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트레드밀 운동이 streptozotocin로 유발된 당뇨쥐 췌장과 신장조직의 항산화 효소와 형태학적 변화에 미치는 영향
이희혁 ( Lee Hui Hyeog ),김성수 ( Kim Seong Su ),김창주 ( Kim Chang Ju ),신말순 ( Sin Mal Sun ),윤진환 ( Yun Jin Hwan ),정일규 ( Jeong Il Gyu ),정경훈 ( Jeong Gyeong Hun ),김영표 ( Kim Yeong Pyo ),김종오 ( Kim Jong O ) 한국운동생리학회 2003 운동과학 Vol.12 No.3
Lee, H.H., Kim, S.S., Kim, C.J., Shin, M.S., Yoon, J.H., Jeong, I.G., Chung, K.H., Kim, Y.P., Kim, J.O. Effects of treadmill exercise on antioxidant enzymes and morphological changes in the pancreas and kidney of streptozotocin-induced diabetic rats. Exercise Science, 12(3): 467-482, 2003. The aim of this study was to examine the effects of exercise on antioxidant enzyme activities and morphology in STZ-induced diabetic pancreas and kidney in rats. Sprague-Dawley rats were divided into three group, 5 rats each: the diabetes group(DG), diabetes+ low-intensity exercise group(DL), and diabetes+moderate-intensity exercise group(DM). Rats of the exercise groups made to run on a motorized treadmill for 30 min once a day for 6 weeks. After 6 weeks, the animals were sacrificed and activities of SOD and CAT and morphology were determined both in pancreas and kidney tissues. Data were expressed as mean±standard error mean (S.E.M). For comparisons between groups, one-way ANOVA and Duncans post-hoc test were performed with P < 0.05 as an indication of statistical significance. Both in pancreas and kidney tissues, the activities of SOD and CAT both in DL and DM groups were significantly higher than in the DG group, but there weren`t any significant differences between the DL and DM groups. The findings from the histological examination showed that the islet size and its cell number weren`t significantly different among three groups, and in degrees of glomerular thickening, there also weren`t different among three groups.
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