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RISS 인기검색어
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- 저자 : 신인식 ( In Sik Shin ) (검색결과 79 건)
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Spargue-Dawley 랫드를 이용한 방풍통성산의 급성독성 연구
신인식,김정훈,하혜경,서창섭,이미영,허정임,신현규,Shin, In-Sik,Kim, Jung-Hoon,Ha, Hye-Kyung,Seo, Chang-Seob,Lee, Mee-Young,Huh, Jung-Im,Shin, Hyeun-Kyoo 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.1
Objectives : This study was conducted to evaluate the acute toxicity and safety of Bangpungtongsung-san (Fangfengtongsheng-san) in Sprague-Dawley rat though the current regulatory guideline. Methods : The preliminary study showed that the single oral administration of Bangpungtongsung-san (Fangfengtongsheng-san) did not induce any toxic effect at a dose level of 2000 mg/kg. Based on the results, 2000 mg/kg was selected as the limited dose. In this study, 10 rats of each sex were randomly assigned to two groups of 5 rats each and were administrated singly by gavage at dose levels of 0 and 2000 mg/kg. Mortalities, clinical signs, and body weight changes were monitored for the 15-day period following administration. At the end of observation period, all animals were sacrificed and complete gross postmortem examinations were performed. Results : Throughout the study period, no treatment-related deaths were observed. There were no adverse effects on clinical signs, body weight, and gross findings at all treatment groups. Conclusions : These results showed that the single oral adminstration of Bangpungtongsung-san (Fangfengtongsheng-san) did not cause any toxic effect at the dose levels of 2000 mg/kg in rats. In conclusion, the $LD_{50}$ of Bangpungtongsung-san (Fangfengtongsheng-san) was considered to be over 2000 mg/kg body for both sexes.
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Spargue-Dawley 랫드를 이용한 구미강활탕의 급성독성 연구
신인식,김정훈,하혜경,서창섭,이미영,이호영,이준경,이남헌,이진아,이설림,허정임,신현규,Shin, In-Sik,Kim, Jung-Hoon,Ha, Hye-Kyung,Seo, Chang-Seob,Lee, Mi-Young,Lee, Ho-Young,Lee, Jun-Kyoung,Lee, Nam-Hun,Lee, Jin-Ah,Lee, Sul-Lim,Huh, Jung-Im 대한한의학방제학회 2010 대한한의학 방제학회지 Vol.18 No.1
Objectives : This study was conducted to evaluate the acute toxicity and safety of Gumiganghwal-tang (Jiuweiqianghou-tang) in Sprague-Dawley rats though the current regulatory guideline. Methods : The preliminary study showed that the single oral administration of Gumiganghwal-tang(Jiuweiqianghou-tang) did not induce any toxic effect at a dose level of 2000 mg/kg. Based on the results, 2000 mg/kg was selected as the limited dose. In this study, 10 rats of each sex were randomly assigned to two groups of 5 rats each and were administrated singly by gavage at dose levels of 0 and 2000 mg/kg. Mortalities, clinical signs, and body weight changes were monitored for the 15-day period following administration. At the end of observation period, all animals were sacrificed and complete gross postmortem examinations were performed. Results : Throughout the study period, no treatment-related deaths were observed. There were no adverse effects on clinical signs, body weight, and gross findings at all treatment groups. Conclusions : These results showed that the single oral adminstration of Gumiganghwal-tang(Jiuweiqianghou-tang) did not cause any toxic effect at the dose levels of 2000 mg/kg in rats. In conclusion, the $LD_{50}$ of Gumiganghwal-tang (Jiuweiqianghou-tang) was considered to be over 2000 mg/kg body for both sexes.
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치은섬유아세포의 MMP 발현에 대한 Nitric Oxide의 영향
신인식,윤상오,정현주,고정태,Shin, In-Sik,Yoon, Sang-Oh,Chung, Hyun-Ju,Koh, Jung-Tae 대한치주과학회 2003 Journal of Periodontal & Implant Science Vol.33 No.2
It has been suggested that increased number and activity of phagocytes in periodontitis lesion results in a high degree of reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide, nitric oxide and peroxynitrite. There are few reports on the relationship between ROS and MMPs expressions in gingival fibroblast. We studied to elucidate whether and how ROS, especially nitric oxide affects the MMP expression. Human gingival fibroblasts and HTl080 cells (human fibrosarcoma sell line as reference) were grown in DMEM supplemented with 10 mM HEPES, 50 mg/L gentamicin, and 10% heat inactivated fetal bovine serum with addition of various reactive oxygen species (ROS). Culture media conditioned by cells were examined by gelatin zymography. HT1080 cells expressed proMMP-2 and proMMP-9, but human gingival fibroblasts (HGF) produced only proMMP-2. Hydrogen peroxide upregulated MMP-9 expression in HT1080 cells, whereas in human gingival fibroblast SNP treatment showed marked increase in MMP-2 level compared to other ROS. These results suggest that the effects of ROS on MMPs expressions are cell-type specific. RT-PCR for MMP-2 and TIMP-2 m-RNA were performed using total RNA from cultured cells under the influence various kinase inhibitors. In HT1080 cells, treatment with FPTI III (Ras processing inhibitor) and LY294002 (PI3-kinase inhibitor) resulted in inhibition of MMP-2 and MMP-9 expressions, suggesting that Ras/P13-kinase pathway is important for MMPs expression in HT1080 cells. In gingival fibroblasts, treatment with FPTI III and PDTC (NF-kB inhibitor) showed marked decrease in MMP-2 regardless of the of SNP , suggesting that Ras/NF-kB could be the key pathway for NO-induced MMP-2 expression in gingival fibroblasts. This study showed that ROS, especially nitric oxide, could be the critical mediator of periodontal disease progression through control of MMP-2 expression in gingival fibroblasts possibly via Ras/NF-kB pathway.
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지역농협의 상대적 효율성 평가를 위한 투입,산출변수 선정에 관한 고찰 -DEA 모형을 중심으로-
신인식 ( In Sik Shin ),최경식 ( Kyung Sik Choi ),남기포 ( Gi Pou Nam ) (사)한국협동조합학회 2011 한국협동조합연구 Vol.29 No.2
DEA is a linear programming for evaluation of comparative efficiency and inefficiency among some units that use multiple inputs for multiple outputs. The purpose of this paper is to review the evaluation of efficiencies by DEA model and the selection of appropriate input and output variables. As a result of this study, I suggest the input and output variables for using the DEA model are as follows; Firstly, selected input variables are the real estate for business, total personnel number including regular and irregular works, per capita, sale and maintenance cost, members of cooperatives and immeasurable items, etc.. Secondly, selected output variables are the volume of credit business, the volume of economic business, effective contract volume of insurance, gross profit, immeasurable items (members satisfaction), etc..
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농업인 감소에 따른 지역농협 조합원 자격제도에 관한 고찰
신인식 ( In Sik Shin ) (사)한국협동조합학회 2013 한국협동조합연구 Vol.31 No.1
The number of farmers decreased due to the aging of agricultural population and change of rural structure. Therefore, the use of non-members in agricultural cooperative business is significantly increasing. From these results, the various segregation of layers such as senior members, exclusive members and sleeping members, etc. This paper was carried out as follows: Firstly, to find the status and problems of Regional Agricultural Cooperative Members in the changing internal and external situation. Secondly, focused on setting up criteria for members is well suited to the reality in Korea.
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