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보기제통탕이 말초신경병증 모델에서 신경 손상 회복에 미치는 영향
박상우,김철중,조충식,Park, Sang-Woo,Kim, Chul-Jung,Cho, Chung-Sik 대한한방내과학회 2013 대한한방내과학회지 Vol.34 No.4
Objectives : Effects of Bogijetong-tang (BJT) on peripheral nerve regeneration have been reported in a previous study on BJT but additional study on a damaged peripheral neuropathy where its damage level is physically and chemically more severe was needed. Plus, this study was conducted because there haven't been any studies for BJT on central nerve regeneration. Methods : In order to check the effect on central nerve regeneration, the study on cerebellum cells was started and the sciatic nerve was used to observe the effects on a peripheral nerve which was severely damaged both physically and chemically. Nerve recovery effects were observed by analyzing target proteins such as phospho-extracellular signal-regulated kinase, ${\beta}1$ integrin, neurofilament 200, growth-associated protein-43, cyclin-dependent kinase 1, phospho-vimentin, phospho-Smad, and caspase 3. Results : The significant changes of target protein in cerebellum neurons have been observed. The changes of index protein on the axon regeneration and the nerve recovery in the sciatic nerve have been observed and the effects on cell protection were observed, as well. Conclusions : This study confirmed that BJT made a significant influence on nerve protection and recovery of a damaged peripheral neuropathy and it also made a possibility of its regeneration in a damaged central nerve injury.
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박상우,전병호,장석환 한국수자원학회 2003 한국수자원학회논문집 Vol.36 No.5
본 연구에서는 강우의 지역빈도분석에 필요한 수문학적 동질성을 갖는 지점강우의 권역화를 수행하였다. 이를 위해 전국에 걸친 기상청 산하의 60개 강우관측소에 대한 32개의 강우특성자료를 추출하였으며, 추출된 각 지점의 많은 강우자료들은 다변량 분석의 자료축약기법인 주성분분석과 그룹화 기법인 군집분석을 통하여 합리적이고 효율적으로 권역화되었다. 본 연구의 결과인 지점강우의 권역은 강우지역을 수문학적 동질성의 5개 권역과 3개의 기타지역으로 분류되었으며, 각 This study has performed the regionalization of point rainfall which has the hydrological homogeneity for regional frequency analysis of the rainfall. For the study, the recorded rainfall data were collected from 60 rainfall gauge stations distributed all
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