신증후군 환아에서 스테로이드에 의한 골다공증 치료에 $1{\alpha}-(OH)D_3$와 Pamidronate의 효과

김성도,전혜원,조병수,Kim Sung-Do,Jhon Hye-One,Cho Byoung-Soo 대한소아신장학회 2002 Childhood kidney diseases Vol.6 No.2

Purpose : Corticosteroid has been used as the mainstay therapy of childhood NS. But SIO is one of the serious complications of long-term steroid therapy, especially in growing children. Recently calcium, calcitonin, PTH, vitamin D and bisphosphonate has been used to treat or prevent SIO in adult, which is rare in children with NS. We studied the effect of $1{\alpha}-(OH)D_3$ and Pamidronate on SIO using dual energy X-ray absorptiometry (DEXA). Patients and methods : We studied thirty patients who admitted in the Dept. of Pediatrics of Kyung Hee Medical Hospital with NS. All patients was received longterm steroid therapy. There was no history of bone, liver, or endocrine disease. The samples, serum protein, albumin, BUN, creatinine, calcium, phosphorus, and BMD were obtained before and the six months after the dose of $1{\alpha}-(OH)D_3$ and Pamidronate, respectively Results : The mean age was $6.9{\pm}3.3\;and\;6.5{\pm}2.5$ years old. The mean duration of steroid therapy was $28.8{\pm}1.8\;and\;27.6{\pm}1.0$ months. The changes of serum protein, albumin, BUN, creatinine, calcium and phosphorus level between pre-treatment and post-treatment did not show statistical significance in both $1{\alpha}-(OH)D_3$ and Pamidronate treatment group. However, BMD was increased in both from $0.472{\pm}0.12\;and\;0.457{\pm}0.10\;g/cm^2\;to\;0.533{\pm}0.12$ and $0.529{\pm}0.09\;g/cm^2$ after treatment. (P<0.05) Conclusion : Both $1{\alpha}-(OH)D_3$ and Pamidronate appears to be effective in treating and preventing SIO in children with nephrotic syndrome requiring long-term steroid therapy.

소아 미세변화 신증후군 환자에서 Apolipoprotein E4 유전자형에 관한 연구

김성도,배영민,조병수,조여원,김일수,Kim Sung-Do,Bae Young-Min,Cho Byoung-Soo,Cho Yoe-Won,Kim Il-Soo Korean Society of Pediatric Nephrology 2001 Childhood kidney diseases Vol.5 No.2

Purpose: We studied to find out apo-E genotype polymorphism in minimal change nephrotic syndrome(MCNS) and IgA nephropathy(IgAN) and to determine the relationship between apo-E genotype and clinical course of MCNS. Materials and Method: 43 MCNS patients and 15 IgAN patients were examined for apo-E polymorphism. 50 healthy blood donors were examined for apo-E genotype as control. Genomic DNA was prepared front peripheral blood leukocytes according to standard procedures. Results: As compared with control group, e4 allele frequency was significantly increased in MCNS (p<0.01). However, in IgAN e2 allele frequency, however, was 2.6 times higher than normal control (P<0.01). The frequency of e4 allele of frequent relapser group was 4.6 times higher than normal control and was 2 times higher than infrequent relapser group. Conclusion: We think that apo-E typing might be one of the parameters, which should be considered to predict the course of MCNS in children. MCNS with risky HLA profile and E4/4 genotype could indicate the need for a longer steroid administration. And apo-E genotype needs to be considered for the evaluation of therapeutic responses to other drugs. (J, Korean Soc Pediatr Nephrol 2001 ; 5 : 87-99)

The Comparison between FSGS and MCNS Using Proteomic Method in Childhood Nephrotic Syndrome; Preliminary Study

김성도,조병수,Kim, Sung-Do,Cho, Byoung-Soo Korean Society of Pediatric Nephrology 2009 Childhood kidney diseases Vol.13 No.2

Purpose : FSGS do not respond well to any kind of therapy and gradually progress to end-stage renal disease. This study was conducted to investigate the difference of protein expression between MCNS and FSGS as a preliminary study for understanding the pathophysiology of FSGS. Methods : Renal biopsy samples of MCNS and FSGS were obtained, which was diagnosed by one pathologist. They were solubilized with a conventional extraction buffer for protein extraction. The solution was applied on immobilized linear gradient strip gel (pH 4-7) using IPGphor system. Silver staining was carried out according to standard method. Protein identification was done by searching NCBI database using MASCOT Peptide Mass Fingerprint software. Results : The differences in protein expressions between MCNS and FSGS were shown by increased or decreased protein spots. Most prominently expressed spot among several spots in FSGS was isolated and analyzed, one of which was glutathione S-transferase (GST) P1-1, whereas it was not found in MCNS. So GSTP1-1 was considered as the one of the key biomarkers in pathogenesis of FSGS. Conclusion : This result would be helpful in diagnosing FSGS and researching FSGS. Further studies for glutathione S-transferase P1-1 might be necessary to elucidate the mechanisms regarding FSGS.

이동통신 중계시스템 가상 계측에 관한 베이지안 방법론 적용

김성도(Sung Do Kim),김종소(Jong So Kim),배석주(Suk Joo Bae) 한국품질경영학회 2015 한국품질경영학회 춘계학술발표논문집 Vol.2015 No.4

축 방향 왕복운동을 하는 외팔보의 안정성 해석을 위한 모델링 및 검증

김성도(Kim, Sung-Do),유홍희(Yoo, Hong-Hee) 한국소음진동공학회 2006 한국소음진동공학회 논문집 Vol.16 No.2

Modeling and verification for stability analysis of axially oscillating cantilever beams are investigated in this paper Equations of motion for the axially oscillating beams are derived and transformed into dimensionless forms. The equations include harmonically oscillating parameters which are related to the motion-induced stiffness variation. stability diagram is obtained by using the multiple scale perturbation method. To verify the accuracy of the modeling method, several points in the plane of the stability diagram are presented and solved. The present modeling method proves to be as accurate as a nonlinear finite element modeling method.

리니어펄스모터의 등가회로에 관한 연구

김성도(Kim Sung Do),김정철(Kim Jung Chul),임태빈(Im Tae Bin),조윤현(Cho Yun Hyun) 대한전기학회 1997 대한전기학회 학술대회 논문집 Vol.1997 No.7

AHP를 이용한 6시그마 프로젝트의 위험요인에 대한 중요도 평가

김성도 ( Sung Do Kim ),박우균 ( Woo Gyun Park ),이용복 ( Yong Bok Lee ),윤덕균 ( Deok Kyun Yun ) 한국경영공학회 2013 한국경영공학회지 Vol.18 No.1

The Six-sigma management is enterprise-wide innovation movement which includes company, customer, process and knowledge. It is necessary to analyze not only success factors also failure factors of Six-sigma to maintain sustainability and to contribute business performance for Six-sigma management. The analysis about success factors and failure factors of Six-sigma is as important as deciding business performance. On the domestic side, there are lots of empirical researches about success factors of Six-sigma how much influence to business performance. And the researches about success factors are being studied actively. But researches of risk factors and failure factors of Six-sigma are insufficient. The Six-sigma project has the ultimate object to remove failure factors beforehand and to contribute business performance. To achieve this, we analyzed KORAIL which starts Six-sigma for the first time from among Korean public enterprises. Through this analysis, we drew risk factors and failure factors which directly influence to Six-sigma project. And we prioritized the formulated factors. As a result, 8 fields and 14 factors have been drawn by stepwise regression and we prioritized the rick factors and failure factors by AHP(Analytic Hierarchy Process). With this, company can effectively manage risk factors and carry out Six-sigma projects. Furthermore, we expect it will contribute business performance.

서울의 공간적 의미 작용에 대한 기호학적 시론

김성도 ( Sung Do Kim ),박상우 ( Sang Woo Park ) 한국기호학회 2006 기호학연구 Vol.19 No.-

도시 브랜딩의 기호학적 접근

김성도 ( Sung Do Kim ) 한국텍스트언어학회 2007 텍스트언어학 Vol.23 No.-

목소리의 형이상학과 기호학

김성도(Kim Sung-Do) 국어국문학회 2007 국어국문학 Vol.- No.146

The purpose on this paper is to provide some semiotic and phenomenological reflection of human voice. The hypothesis of this inquiry can be summarized as follows : The human language would be fundamentally corporal. By definition, major function is to express and to communicate bodily and phenomenological dimension. In fact, this work is inspired by the aesthetic philosophy by Mikel Dufrenne. It should be underlined that the voice is a vast domain of human science. The principal themes might include the relationships between speech and voice, voice and sexual difference, voice and writing, and the moral rules of the voice. In this paper, we will focus on the corporal and aesthetic dimension of the voice and will criticize a limited and reductionist position of modern linguistics on the phenomenological qualities of human voice. This study can be served as an introduction of aesthetics of language.