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연잎, 연꽃, 연꽃 수술 추출물이 UVB 자외선 조사에 의한 각질형성세포의 보호 및 피부 노화 방지에 미치는 영향
장문석 ( Mun Seog Chang ),고은빛 ( Eun Bit Ko ),이호진 ( Ho Jin Lee ),김주성 ( Ju Sung Kim ),김진수 ( Jin Soo Kim ),지성원 ( Sung Won Jee ),김휴영 ( Hyu Young Kim ),염명훈 ( Myeong Hoon Yeom ),김덕희 ( Duck Hee Kim ),김한곤 ( Han 대한본초학회 2011 대한본초학회지 Vol.26 No.2
Objectives: The purpose of this study was to investigate the anti-aging effects on cultured human keratinocytes with Nelumbo nucifera extracts. Methods: Each parts of leaves, flowers and stamen were extracted with water or 70% ethanol. These extracts were tested for cell viability on HaCaT cells (human keratinocyte line) by MTT assay. We investigated the effects of Ultraviolet-B (UVB) irradiation on cytotoxicity and lipid peroxidation in cultured skin keratinocytes. Results: The ethanol extract of Nelumbo nucifera flowers showed maximun cell viability as 111.39% in 30 ug/ml concentration. The water extracts of stamen, flowers, leaves showed cell viability as 107.12, 101.65, 101.46%, respectively. HaCaT keratinocytes were survived 63.06% at 20 mJ/cm2 UVB irradiation. The cell membrane lipid peroxidation was measured by accumulation malondialdehyde (MDA). The levels of MDA were decreased by the ethanol extract of Nelumbo nucifera flowers and the water extracts of stamen. Conclusions: These finding suggest that the ethanol extract of Nelumbo nucifera flowers prevent anti-aging effects on cultured human keratinocytes during UVB irradiation.
SD계 흰쥐에 대한 太陰調胃湯의 급성 경구 독성 시험 연구
장문석(Mun Seog Chang),심경준(Kyung Jun Shim),김휴영(Hyu Young Kim),박은화(Eun Hwa Park),고은빛(Eun Bit Ko),최봉재(Bong Jae Choi),양웅모(Woong Mo Yang),임형호(Hyung Ho Lim),이명종(Myeong Jong Lee),박성규(Seong Kyu Park) 한의병리학회 2008 동의생리병리학회지 Vol.22 No.6
The objective of this study was to evaluate the acute toxicity of Taeumjowi-tang in rats. SPF Sprague-Dawley male and female rats were administered orally with Taeumjowi-tang extract of 2,500 mg/kg(low dosage group), and 5,000 mg/kg(high dosage group). We daily examined number of deaths, clinical signs, body weights and gross findings for 14 days. No dead animal and no significant changes of body weights were found during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, hematology, serum biochemistry, and other findings. In conclusion, Taeumjowi-tang extract did not show any toxic effects, and oral LD50 value was over 5,000 mg/kg in SD rats.