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마이크로 部品의 精密測定을 위한 映像處理 基盤의 에지檢出 技法에 關한 硏究
강성훈 成均館大學校 大學院 2004 국내석사
Over the last decade, rapid development of micro-scale parts and devices, typically manufactured with MEMS and Micro Machining Technologies, has driven strong needs for high precision measurement systems and technologies. Among various high precision measurement techniques, recent progresses in high magnification lenses and high resolution cameras enable researchers to obtain suitably magnified micro scale images and thus many studies on precision measurement technologies based on image processing have been carried out. Among various features of interest in the image processing researches, edge of target image has a wealth of information such as dimension, orientation as well as shape. The edge is typically defined as an intensity value changes between adjacent pixels and various methods are used to precisely detect it. However, the analyzed results are not necessarily identical even for the same exact image depending on applied edge detection methods. Furthermore, most of the edge detection algorithms are developed to enhance the contrast between the target image and the background while leaving the task of actual dimensional measurement to each individual researcher to exploit further. In this paper, the actual dimensional data was measured based on the combination of various edge information such as intensity gradient, intensity value as well as width of interest on an arbitrary line of interest, typically predefined by the researcher. In order to verify the suggested method, a precision measuring instrument which consists of high resolution camera and high power magnifying lens was integrated and used to measure a sample of typical micro parts. As mentioned earlier, the result was obtained on the line of interest and was compared with those measured with other methods. From comparison experiment, it was validated that suggested method was satisfactory for the measurement of micro scale parts and components.
미래지향적 항암제로서 4,5 아미노 싸이아졸 화합물에 대한 합성 및 효능연구
Every Year a large numbers of people died of cancer and also increased the numbers the trend is to continue. These have been used chemotherapy to treat cancer, which Scrap the various metabolic pathways of cancer cells against tumor cells by inducing Representing the cytotoxicity and growth inhibition are collectively drugs. Consequently, we could obtain ideal results through the combination chemistry and our highly efficient search methods (HTS) also promising agent Compound 1 was able to get easily. Substituents attached to the fore a variety of derivatives and also to consider changes in the location we studied thiazole. Toxicity of several cancer cells could do. As a result, cancer cells (HepG2) in the B1 and (Hep3B) in the A1 material for the specificity seems to have learned the truth. Therefore, according to the activity of functional group changes in the process of finding the target protein is considered to be helpful. Depending on the results of the target enzyme inhibitor such as a new lead compound action shall be deemed to be present. 매년 많은 수의 사람들이 암으로 인해 사망하고 또한 그 숫자가 계속해서 증가하는 추세에 있다. 이러한 암을 치료하기 위해 항암제가 이용되고 있는데, 항암제란 암세포의 각종 대사경로에 작용하여 암세포에 대하여 세포독성이나 성장억제효과를 나타내는 약제를 총칭한다. 우리는 조합화학과 고효율 검색방법(HTS)를 통해 보다 암세포에 이상적으로 억제시킬수 있는 대표물질인 화합물 1을 얻을수 있게 되었다. 이물에 다양한 치환기를 붙여 유도체를 만들고 또한 싸이아졸 위치의 변화도 고려해 우리는 여러 간암세포의 독성 실험을 할수 있었다. 그결과 간암세포(HepG2)에서는 B1 물질이, 간암세포(Hep3B)에서는 A1이 암세포에 대한 특이성을 보인다는 사실을 알게되었다. 따라서 작용기에 따른 활성의 변화는 표적단백질을 찾는 과정에서 도움이 될 것으로 사료되며 이 결과에 따라 표적효소 등의 작용억제제로써 새로운 선도 물질을 제시할 수 있을 것으로 본다.
한국의 현대 정치적 지역주의 : 신제도주의적 관점을 중심으로
Since the democratization in 1987, regionalism has occupied the status as the most explanatory factor of Korean politics. It has served as a fortress for democratic forces or opposition parties, resulting in the conditions in which opposition parties overwhelmed ruling parties in terms of the number of the elected. Unfortunately it has also revealed several dilemmas: political parties become personalized; voters and candidates have been thwarted to have free choice; and local politics were taken as hostage for the political power game. It is assumed that several culprits have plotted to bring about the pathological symptoms. Social, cultural and economic, mostly political institutions played key roles in the process. Political elites also jumped on the wagon, employing a strategy of ‘optimization.’ Finally it is a product of passive correspondence, namely the product of the reaction of voters, who are under many limits, which are called the bounded rationality. From this aspect, it seems feasible that new institutionalist viewpoint is needed to explicate the process allowing the regionalism to emerge and the subsequent events. It is because the approach itself utilizes the influence of institutions and autonomous choices of actors in the Korean politics. After a research, it was found out that political factors such as political environment, election system, and political party system are the very ones that have affected regionalism more than anything else. Lopsided recruitment of political elites and economic development have also enabled a political circumstance, the one that political parties too heavily depend on certain areas for their political clout that in turn have served as a material foundation of the confrontation of two provinces, ‘Yeong Nam,’ and ‘Ho Nam,’ the two southern parts of the country. Along with it, regionalism have played a key role as an ideology to activate such political institutions. Yet, it was revealed that the fissure between the metropolitan and the non-metropolitan areas was much wider than that of the Yeong Nam and Ho Nam, revealing that it is the deep bottom of the Korean regionalism. It shows that political regionalism has settled down as an ideology of the political forces that oppose sociial, economic and political centralization. Meanwhile, political elites make their existence as reasonable actors. This leads them to much heavier responsibility in that they have appealed to regional sentiment as a viable method to win votes. At the same time, voters are not free from the outcome either since they have not used their own discretion to discriminate the gimmicks. Therefore, following measures are believed to be vital to overcome the political predicaments: the isolated voters and free-riding political leaders: guaranteeing trust and cooperation for political leaders, and punishment overriding the benefits of complacency for voters Although the measures put a heavy burden on the Korean society as a whole, they would be the way for the members to learn of democratic procedures at the lowest cost.
Bacillus cereus group에 대한 생화학적 동정의 유용성
강성훈 중앙대학교 사회개발대학원 2007 국내석사
Bacillus 속은 아포를 형성하는 그람양성 간균이며 공기 중이나 토양, 물, 먼지 등에 광범위하게 분포한다. Bacillus 속에는 B. anthracis, B. cereus, B. thuringiensis, B. mycoieds, B. weihenstephanensis, B. pseudomycoides 가 포함된다. 특히 이 세균들은 높은 유전학적 상동성으로 인하여 Bacillus cereus group으로 불리고 세균학적, 생화학적, 분자생물학적으로 명확하게 분류 동정하는데 어려움이 있다. 이 연구에서는 B. cereus group 세균 28종을 대상으로 5가지의 세균학적 검사와 61가지의 생화학적(API System) 검사를 시행하여 세균을 분류, 동정하였다. 또한 Multilocus Sequence Typing(MLST) 결과와 비교하여 B. cereus group의 표현형과 유전학적 특성을 동시에 고려한 효과적인 분류, 동정 자료로 활용하고자 하였으며 다음과 같은 결과를 얻었다. API system만을 사용하는 것은 B. cereus group의 정확한 분류, 동정은 어려우며, B. cereus group내의 세균임은 확인이 가능하였다. 세균학적 검사와 API System을 동시에 실시한 결과 실험균주들은 2개 또는 3개의 그룹을 형성하였다. B. anthracis 4종은 미동정바실러스 Rho와 함께 다른 세균들과는 독립적인 소그룹을 형성하였으며 B. mycoides 소그룹과 가장 유사하였다. MLST 결과에서 B. anthracis 4종은 독립적인 소그룹을 형성하였으며, API System 결과와는 다르게 B. thuringiensis와 유사성을 보였다. B. anthracis의 결과를 중심으로 4가지의 세균학적 검사와 61가지 API System 검사 중 22가지를 선택하여 실시한 결과 실험균 28종은 3개의 그룹을 형성하였다. B. anthracis는 미동정바실러스 Rho와 함께 독립적인 그룹을 형성하였고, B. mycoides 5종도 하나의 그룹을 형성하였다. B. cereus, B. thuringiensis, 미동정바실러스는 하나의 큰 그룹을 형성하였는데, 각 균주들은 종별로 3개의 소그룹을 형성하였다. 본 연구를 통하여 API System을 사용하여 B. cereus group임을 확인하고 세균학적 검사를 추가로 시행하여 각 세균을 동정하는 방법은 효과적으로 B. cereus group내의 세균을 분류, 동정하는 방법임을 알 수 있었다. The genus Bacillus is spore-forming, gram-positive, rod-shaped organism commonly found in air, soil, water, dust. The genus Bacillus included B. anthracis, B. cereus, B. thuringiensis, B. mycoides, B. weihenstephanensis, B. pseudomycoides. Specially B. cereus group shares a strong degree of DNA sequence similarity. Furthermore, these species are indistinguishable by the bacteriological, biochemical and molecular analysis, which is widely used for taxonomic studied. For these reasons, it has been proposed that these species be recognized as members of the one species. In this study, 5 bacteriological tests and API system(API 50CHB & API 20E) were performed on 28 strains of Bacillus cereus group. The dendrograms generated from API system showed that the investigated strains were group into 2 to 3 major clusters. 3 strains of B. anthracis(Sterne 34-F2, ATCC14185, ATCC14186) were clustered together, but B. anthracis Pasteur No.2 belonged to different cluster. This dendrogram showed that B. cereus group clearly can not be discriminated and identified by API System. API System and Bacteriological tests revealed that 4 B. anthracis strains in this study were clustered together. 5 strains of B. mycoides and Bacillus spp. Rho belonged to this cluster with B. anthracis. Otherwise in MLST, 4 strains of B. anthracis in this study, were clustered together and closely related to B. thuringiensis. In new method, 4 of 5 bacteriological tests and 22 of 61 API system were performed. The dendrogram showed that the members of B. cereus group generated 3 major clusters. In cluster I, B. cereus, B. thuringiensis and Bacillus spp. formed the sub group respectively. Cluster II encompassed B. anthracis and Bacillus spp. Rho. Last cluster III included B. mycoides. On the basis of these result, the best result was obtained from API system and Bacteriological tests. It is concluded that API System and bacteriological tests could be used for rapid discrimination and identification of B. anthracis and provided an effective means of differentiation between B. cereus group.
루소의 정치철학은 그 핵심을 이루는 두 가지 테제, 즉 “인간의 행동은 비합리적인 동기에 의해 결정된다”는 테제와 “정치권력의 정당성은 구성원 전체의 합리적 행동에 의해 확보된다”라는 테제 간의 모순을 통해 추동력을 얻으며 루소는 이 모순을 교육이 아니라 종교를 통해 조화시키고자 한다. 그런데 루소의 사상을 근간으로 성립했음을 자인하는 자연주의 교육사상은 그것을 교육을 통해, 즉 “인간의 본원적 선성에 기반한 교육” 해결하려 한다는 면에서 루소의 정치철학과는 변별된다. 사실 오늘날 자연주의라고 불리우는 교육사상은 루소로부터 연원한 것이 아니라 근대 독일의 지적 전통 속에서 형성된 것이다. 낭만주의, 이상주의, 고전주의 등은 중세 독일의 신비주의로부터 인간의 본원선에 입각한 “도야(Bildung)”라는 개념을 발견하고 그에 “사회 변화의 수단”으로서의 의미를 부여함으로써, 오늘날 자연주의 교육사상의 원형을 완성했던 것이다. 이후 딜타이를 위시한 정신과학자들은 그 개념을 지속적으로 루소와 함께 호명함으로써 루소의 사상을 범주화하는 일반개념인 자연주의가 그 개념의 이름이 되도록 하는 효과를 생산한다. 본 연구는 그와 같은 루소의 사상체계와 자연주의 교육사상의 변별점 및 그 형성과정을 살펴보는 것을 목적으로 하여 수행되었다.
IEEE 802.11 신호세기 기반 지능형 실내측위 알고리즘 연구
LBS(Location Based Service) is a service which uses position information. LBS is defined in many ways such as GSM defines LBS, " LBS provide personalised services to the user on request, based on their current position.". LBS's core technology is positioning method. Positioning technology is consist of two part: outdoor positioning and indoor positioning. In outdoor positioning, GPS is common technology to get user's position information. And other technologies such as Galileo, GLONASS are used for outdoor positioning. These technologies are using satellite in common for getting user's position. But indoor positioning cannot use GPS. Because limit number of satellite and dilution of GPS signal disturb using GPS in indoor environmental. So recently research institution , laboratory are develop various indoor system which is using various communication technologies such as WLAN(Wireless Local Area Network), RFID(Radio Frequency IDentification), UWB(Ultra WideBand), Ultrasonic, Infrared and e.t.c.. In this thesis, introduce a novel positioning algorithm which uses IEEE 802.11 WLAN RSSI(Received Signal Strength Indicator). RSSI's feature are 1)basic information which is presented by WLAN device, 2)do not create network traffic and 3)easily convert in distance. And in this thesis, introduce an intelligent in-door positioning algorithm. An intelligent in-door positioning algorithm is consist of novel position algorithm, user maintaining radio-map and estimation algorithm about unknown AP(Access Point).